Great baseline plasma degrees of TT may possess scientific applications for managing PCa. = 0.041; OR = 1.004), PSA (p = 0.006; OR = 1.191), and bGS 6 (p = 0.004; OR = 5.0); that’s, a single device upsurge in TT plasma amounts increases the probability of having high quality PCa by 4%. Bottom line In a modern cohort of sufferers, preoperative plasma degrees of TT and independently connected with high quality PCa directly. Great baseline plasma degrees of TT may possess scientific applications for managing PCa. New and smartly designed potential research coping with this subject matter are required. check. Data on categorical factors are provided as proportions, and distinctions between groups had been examined with Pearson’s chi-squared or Fisher’s specific test as suitable. The organizations of high quality PCa was looked into with the logistic regression model where all variables had been entered as constant variables aside from cT (cT1c vs. cT2), bGS (6 vs. 7), and pT (pT2 vs. pT3). All lab tests had been two-sided with p 0.05 thought to indicate statistical significance. Outcomes The present evaluation pertains to 128 sufferers who fulfilled our inclusion requirements. Pathologic and Clinical features of the analysis cohort are reported in desk ?table11 which ultimately shows which the median plasma degree of PSA was 7.5 TT and ng/ml was 331.5 ng/ dl. The cohort demonstrated a median age group of 64.5 years using a median BMI of 26.7 kg/m2. Radical prostatectomy was performed by RARP in 98 (76.6%) situations and connected with extended lymph node dissection in 49 (38.3%) sufferers. Desk 1 Clinical and pathological features of the analysis cohort (n = 128) thead th align=”still left” rowspan=”1″ colspan=”1″ Factors /th th align=”still left” rowspan=”1″ colspan=”1″ Figures /th /thead Continuous (median, range)?Age group (years)64.5 (51C76)?BMI (kg/m2)26.7 (19.6C42.2)?TT (ng/dl)331.5 (116C814)?PSA (ng/ml)7.5 (0.7C25.9)?PV (ml)40 (15C105.0)?P+, percentage0.33 (0.06C1.0)?PSAD, (ng/ml)/ml0.19 (0.01C0.84)Categorical (n, %)?RP??RARP98 (76.6%)??RRP30 (23.4%)?LND (n, %)??no79 (61.7%)??yes49 (38.3%)?cT (n, %)??1c100 (78.1%)??226 (20.3%)??32 (1.6%)?bGS (n, %)??661 (47.7%)??758 (45.3%)?? 79 (7%)?pGS (n, %)??623 (18%)??777 (60.2%)?? 728 (21.8%)?pT (n, %)??2a-b13 (10.2%)??2c86 (67.2%)??3a15 (11.7%)??3b14 (10.9%)?pN (n, %)??045 (35.2%)??16 (4.7%)??x77 (60.2%)?SM (n, %)??(?)96 (75%)??(+) focal16 (12.5%)??(+) multifocal16 (12.5%) Open up in another screen BMI = Body mass index; TT = total testosterone; PV = prostate quantity; P+ = percentage of biopsypositive cores; PSAD = PSA thickness; RP = radical prostatectomy (robotic: RARP; open up: RRP); LND = lymph node dissection; cT = scientific tumor stage; bGS = biopsy Gleason rating; pGS = pathology Gleason rating; pT = tumour pathologic stage; pN = pathologic nodal stage; SM = operative margins. The scientific stage was cT1c in 100 (78.1%) situations and cT2 in 28 (21.9%) sufferers. Tumor quality was discovered as bGS 7 in 9 (7.0%) and pGS 7 in 28 (21.8%) of sufferers. Prostate cancers was organ restricted in 99 (77.4%) situations. Lymph node metastases had been discovered in 6 sufferers (4.7% of the complete cohort). Table ?Desk22 displays the pathological and clinical Mouse monoclonal to A1BG factors that affiliate with low-intermediate tumors (pGS 7, n = 100) vs. high quality malignancies (pGS 7, n = 28). Higher median plasma degrees of TT and PSA favorably associated with high quality PCA that demonstrated lower prices of bGS 6, higher prices of pT3b, and metastatic (pN1) disease. The PSAD was higher in high quality PCa considerably, but there have been no distinctions by age group, BMI, PV, P+, and cT. Desk 2 Clinical and pathological features from the cohort stratified by tumour quality thead th align=”still left” rowspan=”1″ colspan=”1″ Factors /th th align=”still left” rowspan=”1″ colspan=”1″ pGS 7 (n = 100) /th th align=”still left” rowspan=”1″ colspan=”1″ pGS 7 (n = 28) /th th align=”still left” rowspan=”1″ colspan=”1″ p /th /thead Continuous, median (range)?Age group (years)65 (51C76)64 (52C75)0.793?BMI (kg/m2)26.8 (19.6C42.2)26.4 (25.5C34.3)0.863?TT (ng/dl)326.0 (116C814)388 (137C584)0.009?PSA (ng/ml)7.09 (0.71C25.19)9.68 (1.17C25.2)0.002?PV (ml)40 (15C105)41 (18C70)0.626?P+, percentage0.32 (0.006C0.83)0.38 (0.07C1.00)0.087?PSAD (ng/ml/ml)0.17 (0.01C0.71)0.24 (0.03C0.84)0.031Categorical, n (%)?cT0.448??1c82 (64.1)18 (14.1)??217 (13.3)9 (7.0)??31 (0.8)1 (0.8)?bGS 0.0001??655 (48)6 (4.7)??745 (35.2)13 (10.2)?? 70 (0.0)9 GSK 2250665A (7)?pT 0.0001??2 a/b11(8.6)2 (1C6)??2c75 (58.6)11 (8.6)??3a10 (7.8)5 (3.9)??3b4 (3.1)10 (7.8)?pN GSK 2250665A 0.0001?031 (24.2)14(10.9)?11(0.8)5 (3.9)?x68 (53.1)9 (7.0) Open up in another screen BMI = Body mass index; TT = total testosterone; PSA = prostate particular antigen; PV = prostate quantity; P+ = percentage of biopsy positive cores; PSAD = PSA thickness; cT = scientific tumour stage; bGS = biopsy Gleason rating; pT = pathologic tumour stage; pN = pathologic nodal stage; pGS = pathologic Gleason rating. Table ?Desk33 reviews the associations of high quality PCa using the clinical and pathological variables as assessed by logistic regression choices. The evaluation excluded the elements that have been unrelated to high quality prostate cancers. In the univariate model, the factors that connected with pGS 7 had been TT (p = 0.040), PSA (p = 0.002), PSAD (p = 0.031), bGS 6 (p = 0.003),.New and smartly designed prospective research coping with this subject matter are required.. OR = 1.191), and bGS GSK 2250665A 6 (p = 0.004; OR = 5.0); that’s, a single device upsurge in TT plasma amounts increases the probability of having high quality PCa by 4%. Bottom line In a modern cohort of sufferers, preoperative plasma degrees of TT straight and independently connected with high quality PCa. Great baseline plasma degrees of TT may have scientific applications for handling PCa. New and smartly designed potential research coping with this subject matter are required. check. Data on categorical factors are shown as proportions, and distinctions between groups had been examined with Pearson’s chi-squared or Fisher’s specific test as suitable. The organizations of high quality PCa was looked into with the logistic regression model where all variables had been entered as constant variables aside from cT (cT1c vs. cT2), bGS (6 vs. 7), and pT (pT2 vs. pT3). All exams had been two-sided with p 0.05 thought to indicate statistical significance. Outcomes The present evaluation pertains to 128 sufferers who fulfilled our inclusion requirements. Clinical and pathologic features of the analysis cohort are reported in desk ?table11 which ultimately shows the fact that median plasma degree of PSA was 7.5 ng/ml and TT was 331.5 ng/ dl. The cohort demonstrated a median age group of 64.5 years using a median BMI of 26.7 kg/m2. Radical prostatectomy was performed by RARP in 98 (76.6%) situations and connected with extended lymph node dissection in 49 (38.3%) sufferers. Desk 1 Clinical and pathological features of the analysis cohort (n = 128) thead th align=”still left” rowspan=”1″ colspan=”1″ Factors /th th align=”still left” rowspan=”1″ colspan=”1″ Figures /th /thead Continuous (median, range)?Age group (years)64.5 (51C76)?BMI (kg/m2)26.7 (19.6C42.2)?TT (ng/dl)331.5 (116C814)?PSA (ng/ml)7.5 (0.7C25.9)?PV (ml)40 (15C105.0)?P+, percentage0.33 (0.06C1.0)?PSAD, (ng/ml)/ml0.19 (0.01C0.84)Categorical (n, %)?RP??RARP98 (76.6%)??RRP30 (23.4%)?LND (n, %)??no79 (61.7%)??yes49 (38.3%)?cT (n, %)??1c100 (78.1%)??226 (20.3%)??32 (1.6%)?bGS (n, %)??661 (47.7%)??758 (45.3%)?? 79 (7%)?pGS (n, %)??623 (18%)??777 (60.2%)?? 728 (21.8%)?pT (n, %)??2a-b13 (10.2%)??2c86 (67.2%)??3a15 (11.7%)??3b14 (10.9%)?pN (n, %)??045 (35.2%)??16 (4.7%)??x77 (60.2%)?SM (n, %)??(?)96 (75%)??(+) focal16 (12.5%)??(+) multifocal16 (12.5%) Open up in another home window BMI = Body mass index; TT = total testosterone; PV = prostate quantity; P+ = percentage of biopsypositive cores; PSAD = PSA thickness; RP = radical prostatectomy (robotic: RARP; open up: RRP); LND = lymph node dissection; cT = scientific tumor stage; bGS = biopsy Gleason rating; pGS = pathology Gleason rating; pT = tumour pathologic stage; pN = pathologic nodal stage; SM = operative margins. The scientific stage was cT1c in 100 (78.1%) situations and cT2 in 28 (21.9%) sufferers. Tumor quality was discovered as bGS 7 in 9 (7.0%) and pGS 7 in 28 (21.8%) of sufferers. Prostate tumor was organ restricted in 99 (77.4%) situations. Lymph node metastases had been discovered in 6 sufferers (4.7% of the complete cohort). Table ?Desk22 displays the clinical and pathological factors that affiliate with low-intermediate tumors (pGS 7, n = 100) vs. high quality malignancies (pGS 7, n = 28). Higher median plasma degrees of TT and PSA favorably associated with high quality PCA that demonstrated lower prices of bGS 6, higher prices of pT3b, and metastatic (pN1) disease. The PSAD was considerably higher in high quality PCa, but there have been no distinctions by age group, BMI, PV, P+, and cT. Desk 2 Clinical and pathological features from the cohort stratified by tumour quality thead th align=”still left” rowspan=”1″ colspan=”1″ Factors /th th align=”still left” rowspan=”1″ colspan=”1″ pGS 7 (n = 100) /th th align=”still left” rowspan=”1″ colspan=”1″ pGS 7 (n = 28) /th th align=”still left” rowspan=”1″ colspan=”1″ p /th /thead Continuous, median (range)?Age group (years)65 (51C76)64 (52C75)0.793?BMI (kg/m2)26.8 (19.6C42.2)26.4 (25.5C34.3)0.863?TT (ng/dl)326.0 (116C814)388 (137C584)0.009?PSA (ng/ml)7.09 (0.71C25.19)9.68 (1.17C25.2)0.002?PV (ml)40 (15C105)41 (18C70)0.626?P+, percentage0.32 (0.006C0.83)0.38 (0.07C1.00)0.087?PSAD (ng/ml/ml)0.17 (0.01C0.71)0.24 (0.03C0.84)0.031Categorical, GSK 2250665A n (%)?cT0.448??1c82 (64.1)18 (14.1)??217 (13.3)9 (7.0)??31 (0.8)1 (0.8)?bGS 0.0001??655 (48)6 (4.7)??745 (35.2)13 (10.2)?? 70 (0.0)9 (7)?pT 0.0001??2 a/b11(8.6)2 (1C6)??2c75 (58.6)11 (8.6)??3a10 (7.8)5 (3.9)??3b4 (3.1)10 (7.8)?pN 0.0001?031 (24.2)14(10.9)?11(0.8)5 (3.9)?x68 (53.1)9 (7.0) Open up in another home window BMI = Body mass index; TT = total testosterone; PSA = prostate particular antigen; PV = prostate quantity; P+ = percentage of biopsy positive cores; PSAD = PSA thickness; cT = scientific tumour stage; bGS = biopsy Gleason rating; pT = pathologic tumour stage; pN = pathologic nodal stage; pGS = pathologic Gleason rating. Table ?Desk33 reviews the associations of high quality PCa using the clinical and pathological variables as assessed by logistic regression choices. The evaluation excluded the elements that have been unrelated to high quality prostate tumor. In the univariate model, the factors that connected with pGS 7 had been TT (p = 0.040), PSA (p = 0.002), PSAD (p = 0.031),.As a total result, the data of the analysis shows that the distribution of preoperative TT plasma amounts identifies two different populations in the analysis cohort of sufferers who’ve been stratified based on the pGS in low-intermediate and high quality PCa. The results of our clinical super model tiffany livingston claim that independent TT dynamics linked to different grades of PCa may have important applications when getting excited about the natural background of PCa progressing to castration resistance for planning contemporary target therapies by both inhibitors of androgen synthesis, such as for example abiraterone, AR antagonists, such as for example MDV3100, or 5-alpha-reductase inhibitors, such as for example dutasteride [43]. There are many limitations for this investigation. both TT and prostate particular antigen (PSA) had been significantly higher in such cases. In the scientific multivariate model, indie and positive predictors of pGS 7 had been TT (p = 0.041; OR = 1.004), PSA (p = 0.006; OR = 1.191), and bGS 6 (p = 0.004; OR = 5.0); that’s, a single device upsurge in TT plasma amounts increases the probability of having high quality PCa by 4%. Bottom line In a modern cohort of sufferers, preoperative plasma degrees of TT directly and independently associated with high grade PCa. High baseline plasma levels of TT might have clinical applications for managing PCa. New and well designed prospective studies dealing with this subject are required. test. Data on categorical variables are presented as proportions, and differences between groups were analyzed with Pearson’s chi-squared or Fisher’s exact test as appropriate. The associations of high grade PCa was investigated by the logistic regression model in which all variables were entered as continuous variables except for cT (cT1c vs. cT2), bGS (6 vs. 7), and pT (pT2 vs. pT3). All tests were two-sided with p 0.05 considered to indicate statistical significance. Results The present analysis relates to 128 patients who met our inclusion criteria. Clinical and pathologic characteristics of the study cohort are reported in table ?table11 which shows that the median plasma level of PSA was 7.5 ng/ml and TT was 331.5 ng/ dl. The cohort showed a median age of 64.5 years with a median BMI of 26.7 kg/m2. Radical prostatectomy was performed by RARP in 98 (76.6%) cases and associated with extended lymph node dissection in 49 (38.3%) patients. Table 1 Clinical and pathological characteristics of the study cohort (n = 128) thead th align=”left” rowspan=”1″ colspan=”1″ Variables /th th align=”left” rowspan=”1″ colspan=”1″ Statistics /th /thead Continuous (median, range)?Age (years)64.5 (51C76)?BMI (kg/m2)26.7 (19.6C42.2)?TT (ng/dl)331.5 (116C814)?PSA (ng/ml)7.5 (0.7C25.9)?PV (ml)40 (15C105.0)?P+, proportion0.33 (0.06C1.0)?PSAD, (ng/ml)/ml0.19 (0.01C0.84)Categorical (n, %)?RP??RARP98 (76.6%)??RRP30 (23.4%)?LND (n, %)??no79 (61.7%)??yes49 (38.3%)?cT (n, %)??1c100 (78.1%)??226 (20.3%)??32 (1.6%)?bGS (n, %)??661 (47.7%)??758 (45.3%)?? 79 (7%)?pGS (n, %)??623 (18%)??777 (60.2%)?? 728 (21.8%)?pT (n, %)??2a-b13 (10.2%)??2c86 (67.2%)??3a15 (11.7%)??3b14 (10.9%)?pN (n, %)??045 (35.2%)??16 (4.7%)??x77 (60.2%)?SM (n, %)??(?)96 (75%)??(+) focal16 (12.5%)??(+) multifocal16 (12.5%) Open in a separate window BMI = Body mass index; TT = total testosterone; PV = prostate volume; P+ = proportion of biopsypositive cores; PSAD = PSA density; RP = radical prostatectomy (robotic: RARP; open: RRP); LND = lymph node dissection; cT = clinical tumor stage; bGS = biopsy Gleason score; pGS = pathology Gleason score; pT = tumour pathologic stage; pN = pathologic nodal stage; SM = surgical margins. The clinical stage was cT1c in 100 (78.1%) cases and cT2 in 28 (21.9%) patients. Tumor grade was detected as bGS 7 in 9 (7.0%) and pGS 7 in 28 (21.8%) of patients. Prostate cancer was organ confined in 99 (77.4%) cases. Lymph node metastases were detected in 6 patients (4.7% of the entire cohort). Table ?Table22 shows the clinical and pathological variables that associate with low-intermediate tumors (pGS 7, n = 100) vs. high grade cancers (pGS 7, n = 28). Higher median plasma levels of TT and PSA positively associated with high grade PCA that showed lower rates of bGS 6, higher rates of pT3b, and metastatic (pN1) disease. The PSAD was significantly higher in high grade PCa, but there were no differences by age, BMI, PV, P+, and cT. Table 2 Clinical and pathological characteristics of the cohort stratified by tumour grade thead th align=”left” rowspan=”1″ colspan=”1″ Variables /th th align=”left” rowspan=”1″ colspan=”1″ pGS 7 (n = 100) /th th align=”left” rowspan=”1″ colspan=”1″ pGS 7 (n = 28) /th th align=”left” rowspan=”1″ colspan=”1″ p /th /thead Continuous, median (range)?Age (years)65 (51C76)64 (52C75)0.793?BMI (kg/m2)26.8 (19.6C42.2)26.4 (25.5C34.3)0.863?TT (ng/dl)326.0 (116C814)388 (137C584)0.009?PSA (ng/ml)7.09 (0.71C25.19)9.68 (1.17C25.2)0.002?PV (ml)40 (15C105)41 (18C70)0.626?P+, proportion0.32 (0.006C0.83)0.38 (0.07C1.00)0.087?PSAD (ng/ml/ml)0.17 (0.01C0.71)0.24 (0.03C0.84)0.031Categorical, n (%)?cT0.448??1c82 (64.1)18 (14.1)??217 (13.3)9 (7.0)??31 (0.8)1 (0.8)?bGS 0.0001??655 (48)6 (4.7)??745 (35.2)13 (10.2)?? 70 (0.0)9 (7)?pT 0.0001??2 a/b11(8.6)2 (1C6)??2c75 (58.6)11 (8.6)??3a10 (7.8)5 (3.9)??3b4 (3.1)10 (7.8)?pN 0.0001?031 (24.2)14(10.9)?11(0.8)5 (3.9)?x68 (53.1)9 (7.0) Open in a separate window BMI = Body mass index; TT = total testosterone; PSA = prostate specific antigen; PV = prostate volume; P+ = proportion of biopsy positive cores; PSAD = PSA density; cT = clinical tumour stage; bGS = biopsy Gleason score; pT = pathologic tumour stage; pN = pathologic nodal stage; pGS = pathologic Gleason score. Table ?Table33 reports the associations of high grade PCa with the clinical and pathological variables as assessed by logistic regression models. The analysis excluded the factors which were unrelated to high grade prostate cancer. In the univariate model, the variables that associated with pGS 7 were TT (p = 0.040), PSA (p = 0.002), PSAD (p = 0.031), bGS 6.Pretreatment baseline plasma levels of TT, which is an independent factor assessing tumor grade, might have clinical applications for managing PCa. odds of having high grade PCa by 4%. Conclusion In a contemporary cohort of patients, preoperative plasma levels of TT directly and independently associated with high grade PCa. High baseline plasma levels of TT might have clinical applications for managing PCa. New and well designed prospective studies dealing with this subject are required. test. Data on categorical variables are presented as proportions, and differences between groups were analyzed with Pearson’s chi-squared or Fisher’s exact test as appropriate. The associations of high grade PCa was investigated by the logistic regression model in which all variables were entered as continuous variables except for cT (cT1c vs. cT2), bGS (6 vs. 7), and pT (pT2 vs. pT3). All tests were two-sided with p 0.05 considered to indicate statistical significance. Results The present analysis relates to 128 individuals who met our inclusion criteria. Clinical and pathologic characteristics of the study cohort are reported in table ?table11 which shows the median plasma level of PSA was 7.5 ng/ml and TT was 331.5 ng/ dl. The cohort showed a median age of 64.5 years having a median BMI of 26.7 kg/m2. Radical prostatectomy was performed by RARP in 98 (76.6%) instances and associated with extended lymph node dissection in 49 (38.3%) individuals. Table 1 Clinical and pathological characteristics of the study cohort (n = 128) thead th align=”remaining” rowspan=”1″ colspan=”1″ Variables /th th align=”remaining” rowspan=”1″ colspan=”1″ Statistics /th /thead Continuous (median, range)?Age (years)64.5 (51C76)?BMI (kg/m2)26.7 (19.6C42.2)?TT (ng/dl)331.5 (116C814)?PSA (ng/ml)7.5 (0.7C25.9)?PV (ml)40 (15C105.0)?P+, proportion0.33 (0.06C1.0)?PSAD, (ng/ml)/ml0.19 (0.01C0.84)Categorical (n, %)?RP??RARP98 (76.6%)??RRP30 (23.4%)?LND (n, %)??no79 (61.7%)??yes49 (38.3%)?cT (n, %)??1c100 (78.1%)??226 (20.3%)??32 (1.6%)?bGS (n, %)??661 (47.7%)??758 (45.3%)?? 79 (7%)?pGS (n, %)??623 (18%)??777 (60.2%)?? 728 (21.8%)?pT (n, %)??2a-b13 (10.2%)??2c86 (67.2%)??3a15 (11.7%)??3b14 (10.9%)?pN (n, %)??045 (35.2%)??16 (4.7%)??x77 (60.2%)?SM (n, %)??(?)96 (75%)??(+) focal16 (12.5%)??(+) multifocal16 (12.5%) Open in a separate windowpane BMI = Body mass index; TT = total testosterone; PV = prostate volume; P+ = proportion of biopsypositive cores; PSAD = PSA denseness; RP = radical prostatectomy (robotic: RARP; open: RRP); LND = lymph node dissection; cT = medical tumor stage; bGS = biopsy Gleason score; pGS = pathology Gleason score; pT = tumour pathologic stage; pN = pathologic nodal stage; SM = medical margins. The medical stage was cT1c in 100 (78.1%) instances and cT2 in 28 (21.9%) individuals. Tumor grade was recognized as bGS 7 in 9 (7.0%) and pGS 7 in 28 (21.8%) of individuals. Prostate malignancy was organ limited in 99 (77.4%) instances. Lymph node metastases were recognized in 6 individuals (4.7% of the entire cohort). Table ?Table22 shows the clinical and pathological variables that associate with low-intermediate tumors (pGS 7, n = 100) vs. high grade cancers (pGS 7, n = 28). Higher median plasma levels of TT and PSA positively associated with high grade PCA that showed lower rates of bGS 6, higher rates of pT3b, and metastatic (pN1) disease. The PSAD was significantly higher in high grade PCa, but there were no variations by age, BMI, PV, P+, and cT. Table 2 Clinical and pathological characteristics of the cohort stratified by tumour grade thead th align=”remaining” rowspan=”1″ colspan=”1″ Variables /th th align=”remaining” rowspan=”1″ colspan=”1″ pGS 7 (n.So far, the model suggests that the switch in the log-odds of pGS 7 by just one unit increase in TT plasma levels is 1.004, which means that one unit increase in TT plasma levels, evaluated as a continuous variable, increases the odds of high grade PCa by 4%. specific antigen (PSA) were significantly higher in these cases. In the medical multivariate model, self-employed and positive predictors of pGS 7 were TT (p = 0.041; OR = 1.004), PSA (p = 0.006; OR = 1.191), and bGS 6 (p = 0.004; OR = 5.0); that is, a single unit increase in TT plasma levels increases the odds of having high grade PCa by 4%. Summary In a contemporary cohort of individuals, preoperative plasma levels of TT directly and independently associated with high grade PCa. Large baseline plasma levels of TT might have medical applications for controlling PCa. New and well designed prospective studies dealing with this subject are required. test. Data on categorical variables are offered as proportions, and differences between groups were analyzed with Pearson’s chi-squared or Fisher’s exact test as appropriate. The associations of high grade PCa was investigated by the logistic regression model in which all variables were entered as continuous variables except for cT (cT1c vs. cT2), bGS (6 vs. 7), and pT (pT2 vs. pT3). All assessments were two-sided with p 0.05 considered to indicate statistical significance. Results The present analysis relates to 128 patients who met our inclusion criteria. Clinical and pathologic characteristics of the study cohort are reported in table ?table11 which shows that this median plasma level of PSA was 7.5 ng/ml and TT was 331.5 ng/ dl. The cohort showed a median age of 64.5 years with a median BMI of 26.7 kg/m2. Radical prostatectomy was performed by RARP in 98 (76.6%) cases and associated with extended lymph node dissection in 49 (38.3%) patients. Table 1 Clinical and pathological characteristics of the study cohort (n = 128) thead th align=”left” rowspan=”1″ colspan=”1″ Variables /th th align=”left” rowspan=”1″ colspan=”1″ Statistics /th /thead Continuous (median, range)?Age (years)64.5 (51C76)?BMI (kg/m2)26.7 (19.6C42.2)?TT (ng/dl)331.5 (116C814)?PSA (ng/ml)7.5 (0.7C25.9)?PV (ml)40 (15C105.0)?P+, proportion0.33 (0.06C1.0)?PSAD, (ng/ml)/ml0.19 (0.01C0.84)Categorical (n, %)?RP??RARP98 (76.6%)??RRP30 (23.4%)?LND (n, %)??no79 (61.7%)??yes49 (38.3%)?cT (n, %)??1c100 (78.1%)??226 (20.3%)??32 (1.6%)?bGS (n, %)??661 (47.7%)??758 (45.3%)?? 79 (7%)?pGS (n, %)??623 (18%)??777 (60.2%)?? 728 (21.8%)?pT (n, %)??2a-b13 (10.2%)??2c86 (67.2%)??3a15 (11.7%)??3b14 (10.9%)?pN (n, %)??045 (35.2%)??16 (4.7%)??x77 (60.2%)?SM (n, %)??(?)96 (75%)??(+) focal16 (12.5%)??(+) multifocal16 (12.5%) Open in a separate windows BMI = Body mass index; TT = total testosterone; PV = prostate volume; P+ = proportion of biopsypositive cores; PSAD = PSA density; RP = radical prostatectomy (robotic: RARP; open: RRP); LND = lymph node dissection; cT = clinical tumor stage; bGS = biopsy Gleason score; pGS = pathology Gleason score; pT = tumour pathologic stage; pN = pathologic nodal stage; SM = surgical margins. The clinical stage was cT1c in 100 (78.1%) cases and cT2 in 28 (21.9%) patients. Tumor grade was detected as bGS 7 in 9 (7.0%) and pGS 7 in 28 (21.8%) of patients. Prostate malignancy was organ confined in 99 (77.4%) cases. Lymph node metastases were detected in 6 patients (4.7% of the entire cohort). Table ?Table22 shows the clinical and pathological variables that associate with low-intermediate tumors (pGS 7, n = 100) vs. high grade cancers (pGS 7, n = 28). Higher median plasma levels of TT and PSA positively associated with high grade PCA that showed lower rates of bGS 6, higher rates of pT3b, and metastatic (pN1) disease. The PSAD was significantly higher in high grade PCa, but there were no differences by age, BMI, PV, P+, and cT. Table 2 Clinical and pathological characteristics of the cohort stratified by tumour grade thead th align=”left” rowspan=”1″ colspan=”1″ Variables /th th align=”left” rowspan=”1″ colspan=”1″ pGS 7 (n = 100) /th th.